AUTHOR=Ahmad Jawid Nazir , Sebo Peter 

TITLE=Adenylate Cyclase Toxin Tinkering With Monocyte-Macrophage Differentiation

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.02181

DOI=10.3389/fimmu.2020.02181

ISSN=1664-3224

ABSTRACT=<p>Circulating inflammatory monocytes are attracted to infected mucosa and differentiate into macrophage or dendritic cells endowed with enhanced bactericidal and antigen presenting capacities. In this brief Perspective we discuss the newly emerging insight into how the cAMP signaling capacity of <italic>Bordetella pertussis</italic> adenylate cyclase toxin manipulates the differentiation of monocytes and trigger dedifferentiation of the alveolar macrophages to facilitate bacterial colonization of human airways.</p>