AUTHOR=Pali-Schöll Isabella , DeBoer Douglas J. , Alessandri Claudia , Seida Ahmed Adel , Mueller Ralf S. , Jensen-Jarolim Erika 

TITLE=Formulations for Allergen Immunotherapy in Human and Veterinary Patients: New Candidates on the Horizon

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01697

DOI=10.3389/fimmu.2020.01697

ISSN=1664-3224

ABSTRACT=<p>Allergen immunotherapy is currently the only causal treatment for allergic diseases in human beings and animals. It aims to re-direct the immune system into a tolerogenic or desensitized state. Requirements include clinical efficacy, safety, and schedules optimizing patient or owner compliance. To achieve these goals, specific allergens can be formulated with adjuvants that prolong tissue deposition and support uptake by antigen presenting cells, and/or provide a beneficial immunomodulatory action. Here, we depict adjuvant formulations being investigated for human and veterinary allergen immunotherapy.</p>