AUTHOR=Pattyn Jade , Van Keer Severien , Téblick Laura , Van Damme Pierre , Vorsters Alex 

TITLE=Non-invasive Assessment of Vaccine-Induced HPV Antibodies via First-Void Urine

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01657

DOI=10.3389/fimmu.2020.01657

ISSN=1664-3224

ABSTRACT=<p>The potential of first-void (FV) urine as a non-invasive method to monitor human papillomavirus (HPV) vaccination has been reported, mainly focusing on urine as a sample to assess HPV DNA. Besides HPV DNA, vaccine-induced HPV antibodies originating from cervicovaginal secretions were recently shown to be detectable in FV urine as well. This presents a novel opportunity for non-invasive sampling to monitor HPV antibody status in women participating in large epidemiological studies and HPV vaccine trials. The simultaneous assessment of both HPV infection and immunogenicity on a non-invasive, readily obtained sample is particularly attractive.</p>