AUTHOR=Ma Rulan , Yuan Dawei , Guo Yizhan , Yan Rong , Li Kang 

TITLE=Immune Effects of γδ T Cells in Colorectal Cancer: A Review

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01600

DOI=10.3389/fimmu.2020.01600

ISSN=1664-3224

ABSTRACT=<p>Gamma delta (γδ) T cells can effectively recognize and kill colorectal cancer (CRC) cells, thereby suppressing tumor progression <italic>via</italic> multiple mechanisms. They also have abilities to exert a protumor effect <italic>via</italic> secreting interleukin-17 (IL-17). γδ T cells have been selected as potential immunocytes for antitumor treatment because of their significant cytotoxic activity. Immunotherapy is another potential anti-CRC strategy after an operation, chemotherapy, and radiotherapy. γδ T cell-based immunotherapy for CRC shows fewer side effects and better toleration. This review will outline the immune functions and the mechanisms of γδ T cells in the growth and progression of CRC in recent years, and summarize the immunotherapies based on γδ T cells, thus providing a direction for future γδ T cells in CRC research.</p>