AUTHOR=Ferrad Melissa , Ghazzaui Nour , Issaoui Hussein , Cook-Moreau Jeanne , Denizot Yves 

TITLE=Mouse Models of c-myc Deregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01564

DOI=10.3389/fimmu.2020.01564

ISSN=1664-3224

ABSTRACT=<p>Chromosomal translocations linking various oncogenes to transcriptional enhancers of the immunoglobulin heavy chain (IgH) locus are often implicated as the cause of B-cell malignancies. Two major IgH transcriptional enhancers have been reported so far. The E<sub>μ</sub> enhancer located upstream of the C<sub>μ</sub> gene controls early events in B-cell maturation such as VDJ recombination. The 3' regulatory region (3'RR) located downstream from the C<sub>α</sub> gene controls late events in B-cell maturation such as IgH transcription, somatic hypermutation, and class switch recombination. Convincing demonstrations of the essential contributions of both E<sub>μ</sub> and 3'RR in B-cell lymphomagenesis have been provided by transgenic and knock-in animal models which bring the oncogene <italic>c-myc</italic> under E<sub>μ</sub>/3'RR transcriptional control. This short review summarizes the different mouse models so far available and their interests/limitations for progress in our understanding of human <italic>c-myc</italic>-induced B-cell lymphomagenesis.</p>