AUTHOR=Ge Yun , Huang Man , Yao Yong-ming 

TITLE=Biology of Interleukin-17 and Its Pathophysiological Significance in Sepsis

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01558

DOI=10.3389/fimmu.2020.01558

ISSN=1664-3224

ABSTRACT=<p>The interleukin (IL)-17 family includes six structure-related cytokines (A–F). To date, majority of studies have focused on IL-17A. IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. Several recent studies have indicated that IL-17A is a biomarker as well as a therapeutic target in sepsis. In the current review, we summarize the biological functions of IL-17, including IL-17-mediated responses and signal transduction pathways, with particular emphasis on clinical relevance to sepsis.</p>