AUTHOR=Lebegge Els , Arnouk Sana M. , Bardet Pauline M. R. , Kiss Máté , Raes Geert , Van Ginderachter Jo A. 

TITLE=Innate Immune Defense Mechanisms by Myeloid Cells That Hamper Cancer Immunotherapy

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01395

DOI=10.3389/fimmu.2020.01395

ISSN=1664-3224

ABSTRACT=<p>Over the past decade, cancer immunotherapy has been steering immune responses toward cancer cell eradication. However, these immunotherapeutic approaches are hampered by the tumor-promoting nature of myeloid cells, including monocytes, macrophages, and neutrophils. Despite the arsenal of defense strategies against foreign invaders, myeloid cells succumb to the instructions of an established tumor. Interestingly, the most primordial defense responses employed by myeloid cells against pathogens, such as complement activation, antibody-dependent cell cytotoxicity and phagocytosis, actually seem to favor cancer progression. In this review, we discuss how rudimentary defense mechanisms deployed by myeloid cells can promote tumor progression.</p>