AUTHOR=Garelli Colton J. , Refat Maggi Ahmed , Nanaware Padma P. , Ramirez-Ortiz Zaida G. , Rashighi Mehdi , Richmond Jillian M. 

TITLE=Current Insights in Cutaneous Lupus Erythematosus Immunopathogenesis

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01353

DOI=10.3389/fimmu.2020.01353

ISSN=1664-3224

ABSTRACT=<p>Cutaneous Lupus Erythematosus (CLE) is a clinically diverse group of autoimmune skin diseases with shared histological features of interface dermatitis and autoantibodies deposited at the dermal–epidermal junction. Various genetic and environmental triggers of CLE promote infiltration of T cells, B cells, neutrophils, antigen presenting cells, and NK cells into lesional skin. In this mini-review, we will discuss the clinical features of CLE, insights into CLE immunopathogenesis, and novel treatment approaches.</p>