AUTHOR=Dierking Katja , Pita Lucía 

TITLE=Receptors Mediating Host-Microbiota Communication in the Metaorganism: The Invertebrate Perspective

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.01251

DOI=10.3389/fimmu.2020.01251

ISSN=1664-3224

ABSTRACT=<p>Multicellular organisms live in close association with a plethora of microorganism, which have a profound effect on multiple host functions. As such, the microbiota and its host form an intimate functional entity, termed the metaorganism or holobiont. But how does the metaorganism communicate? Which receptors recognize microbial signals, mediate the effect of the microbiota on host physiology or regulate microbiota composition and homeostasis? In this review we provide an overview on the function of different receptor classes in animal host-microbiota communication. We put a special focus on invertebrate hosts, including both traditional invertebrate models such as <italic>Drosophila melanogaster</italic> and <italic>Caenorhabditis elegans</italic> and “non-model” invertebrates in microbiota research. Finally, we highlight the potential of invertebrate systems in studying mechanism of host-microbiota interactions.</p>