AUTHOR=Carnino Jonathan M. , Ni Kareemah , Jin Yang 

TITLE=Post-translational Modification Regulates Formation and Cargo-Loading of Extracellular Vesicles

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00948

DOI=10.3389/fimmu.2020.00948

ISSN=1664-3224

ABSTRACT=<p>Accumulating evidence suggests that post-translational modifications (PTMs) regulate the selective encapsulation of non-coding RNA molecules into extracellular vesicles (EVs) and contribute to the downstream functions of EVs or EV-cargo non-coding RNAs. EVs are a newly studied mechanism of intercellular communication that involves the transfer of molecules, including but not limited to proteins, lipids, and non-coding RNAs, to induce functional changes in the recipient cells. In this present mini-review, we focus on the PTM-regulated protein and non-coding RNA selection into eukaryotic EVs.</p>