AUTHOR=Wang Ming-Yu , Zhou Hai-Hong , Zhang Chun-Miao , Su Hai-Xiang , Li Shuo-Lei , Ji Shang-Rong , Liu Enqi , Wu Yi 

TITLE=A Functional Genetic Variant at the C-Reactive Protein Promoter (rs3091244) Is Not Associated With Cancer Risk in a Chinese Population

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00926

DOI=10.3389/fimmu.2020.00926

ISSN=1664-3224

ABSTRACT=<p><bold>Background:</bold> The association of genetically elevated levels of circulating C-reactive protein (CRP) with cancer risk has been extensively investigated in European populations; however, there are conflicting conclusions. The tri-allelic rs3091244 is a functionally validated genetic variant, and its allelic frequencies differ significantly between European and Asian populations. Here, we examined the association of rs3091244 with cancer risk in a Chinese population.</p><p><bold>Methods:</bold> rs3091244 was genotyped by Sanger sequencing in 4,971 cancer cases and 2,485 controls. The rs1205 and rs2794521 gene variants were also genotyped using TaqMan assays in subgroups.</p><p><bold>Results:</bold> No association was detected between the genotyped CRP variants and cancer risk, with or without distinguishing cancer types, suggesting that circulating CRP is not causally involved in tumorigenesis in Chinese populations.</p>