AUTHOR=Pégorier Perrine , Bertignac Morgane , Chentli Imène , Nguefack Ngoune Viviane , Folch Géraldine , Jabado-Michaloud Joumana , Hadi-Saljoqi Saida , Giudicelli Véronique , Duroux Patrice , Lefranc Marie-Paule , Kossida Sofia 

TITLE=IMGT® Biocuration and Comparative Study of the T Cell Receptor Beta Locus of Veterinary Species Based on Homo sapiens TRB

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00821

DOI=10.3389/fimmu.2020.00821

ISSN=1664-3224

ABSTRACT=<p>IMGT®, the international ImMunoGeneTics information system® is the global reference in immunogenetics and immunoinformatics. By its creation in 1989 by Marie-Paule Lefranc (Université de Montpellier and CNRS), IMGT® marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT® is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamilies. T cell receptors are divided into two groups, αβ and γδ TR, which express distinct TR containing either α and β, or γ and δ chains, respectively. The TRβ locus (TRB) was recently described and annotated by IMGT® biocurators for several veterinary species, i.e., cat (<italic>Felis catus</italic>), dog (<italic>Canis lupus familiaris</italic>), ferret (<italic>Mustela putorius furo</italic>), pig (<italic>Sus scrofa</italic>), rabbit (<italic>Oryctolagus cuniculus</italic>), rhesus monkey (<italic>Macaca mulatta</italic>), and sheep (<italic>Ovis aries</italic>). The aim of the present study is to compare the genes of the TRB locus among these different veterinary species based on <italic>Homo sapiens</italic>. The results reveal that there are similarities but also differences including the number of genes by subgroup which may demonstrate duplications and/or deletions during evolution.</p>