AUTHOR=Cheng Chih-Hsien , Lee Chen-Fang , Oh Byoung Chol , Furtmüller Georg J. , Patel Chirag H. , Brandacher Gerald , Powell Jonathan D. 

TITLE=Targeting Metabolism as a Platform for Inducing Allograft Tolerance in the Absence of Long-Term Immunosuppression

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00572

DOI=10.3389/fimmu.2020.00572

ISSN=1664-3224

ABSTRACT=<p>Transplant tolerance in the absence of long-term immunosuppression has been an elusive goal for solid organ transplantation. Recently, it has become clear that metabolic reprogramming plays a critical role in promoting T cell activation, differentiation, and function. Targeting metabolism can preferentially inhibit T cell effector generation while simultaneously promoting the generation of T regulatory cells. We hypothesized that costimulatory blockade with CTLA4Ig in combination with targeting T cell metabolism might provide a novel platform to promote the induction of transplant tolerance.</p>