AUTHOR=Hoogeveen Ruben C. , Boonstra André TITLE=Checkpoint Inhibitors and Therapeutic Vaccines for the Treatment of Chronic HBV Infection JOURNAL=Frontiers in Immunology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00401 DOI=10.3389/fimmu.2020.00401 ISSN=1664-3224 ABSTRACT=
Treatment of chronic hepatitis B virus (HBV) infection is highly effective in suppressing viral replication, but complete cure is rarely achieved. In recent years, substantial progress has been made in the development of immunotherapy to treat cancer. Applying these therapies to improve the management of chronic HBV infection is now being attempted, and has become an area of active research. Immunotherapy with vaccines and checkpoint inhibitors can boost T cell functions