AUTHOR=Zhou Yifan , Cui Chunping , Ma Xiaoyu , Luo Wenjing , Zheng Song Guo , Qiu Wei 

TITLE=Nuclear Factor κB (NF-κB)–Mediated Inflammation in Multiple Sclerosis

JOURNAL=Frontiers in Immunology

VOLUME=11

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00391

DOI=10.3389/fimmu.2020.00391

ISSN=1664-3224

ABSTRACT=<p>The nuclear factor κB (NF-κB) signaling cascade has been implicating in a broad range of biological processes, including inflammation, cell proliferation, differentiation, and apoptosis. The past three decades have witnessed a great progress in understanding the impact of aberrant NF-κB regulation on human autoimmune and inflammatory disorders. In this review, we discuss how aberrant NF-κB activation contributes to multiple sclerosis, a typical inflammatory demyelinating disease of the central nervous system, and its involvement in developing potential therapeutic targets.</p>