AUTHOR=Jin Zheng , Zhu Zhenhua , Liu Shanshan , Hou Yuyang , Tang Mengyan , Zhu Pei , Tian Yuan , Li Dong , Yan Dongmei , Zhu Xun TITLE=TRIM59 Protects Mice From Sepsis by Regulating Inflammation and Phagocytosis in Macrophages JOURNAL=Frontiers in Immunology VOLUME=11 YEAR=2020 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2020.00263 DOI=10.3389/fimmu.2020.00263 ISSN=1664-3224 ABSTRACT=
Sepsis is associated with bacterial invasion and inflammation and has a high mortality rate. Previous studies have demonstrated that tripartite motif 59 (TRIM59) was involved in NF-κB signaling and could promote phagocytosis of macrophages, but the role of TRIM59 in sepsis is still unknown. In our study, we found that TRIM59 was downregulated in lipopolysaccharide (LPS)-stimulated bone marrow-derived macrophages (BMDMs). In the cecal ligation and puncture (CLP) sepsis mice model, the mortality of