AUTHOR=Vazquez Jessica , Chasman Deborah A. , Lopez Gladys E. , Tyler Chanel T. , Ong Irene M. , Stanic Aleksandar K. 

TITLE=Transcriptional and Functional Programming of Decidual Innate Lymphoid Cells

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.03065

DOI=10.3389/fimmu.2019.03065

ISSN=1664-3224

ABSTRACT=<p>A successful pregnancy requires many physiological adaptations from the mother, including the establishment of tolerance toward the semiallogeneic fetus. Innate lymphoid cells (ILCs) have arisen as important players in immune regulation and tissue homeostasis at mucosal and barrier surfaces. Dimensionality reduction and transcriptomic analysis revealed the presence of two novel CD56<sup>Bright</sup> decidual ILCs that express low T-bet and divergent Eomes levels. Transcriptional correlation with recently identified first trimester decidual dNKs suggests that these novel decidual ILCs might be present throughout pregnancy. Functional testing with permutation analysis revealed production of multiple factors by individual cells, with a preference for IFNγ and VEGF. Overall, our data suggests continuity of a unique decidual innate lymphocytes across pregnancy with a polyfunctional functional profile conducive for pregnancy</p>