AUTHOR=Luo Ying , Meyer Nicole , Jiao Qingqing , Scheffel Jörg , Zimmermann Carolin , Metz Martin , Zenclussen Ana , Maurer Marcus , Siebenhaar Frank TITLE=Chymase-Cre; Mcl-1fl/fl Mice Exhibit Reduced Numbers of Mucosal Mast Cells JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.02399 DOI=10.3389/fimmu.2019.02399 ISSN=1664-3224 ABSTRACT=
Mast cells (MCs) are considered as key effector cells in the elicitation of allergic symptoms, and they are essential players in innate and adaptive immune responses. In mice, two main types of MCs have been described: connective tissue MCs (CTMCs) and mucosal MCs (MMCs). However, little is known about the biological functions of MMCs, which is due to the lack of suitable models to investigate MMCs