AUTHOR=Urban-Wojciuk Zuzanna , Khan Mohd M. , Oyler Benjamin L. , Fåhraeus Robin , Marek-Trzonkowska Natalia , Nita-Lazar Aleksandra , Hupp Ted R. , Goodlett David R. 

TITLE=The Role of TLRs in Anti-cancer Immunity and Tumor Rejection

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.02388

DOI=10.3389/fimmu.2019.02388

ISSN=1664-3224

ABSTRACT=<p>In recent years, a lot of scientific interest has focused on cancer immunotherapy. Although chronic inflammation has been described as one of the hallmarks of cancer, acute inflammation can actually trigger the immune system to fight diseases, including cancer. Toll-like receptor (TLR) ligands have long been used as adjuvants for traditional vaccines and it seems they may also play a role enhancing efficiency of tumor immunotherapy. The aim of this perspective is to discuss the effects of TLR stimulation in cancer, expression of various TLRs in different types of tumors, and finally the role of TLRs in anti-cancer immunity and tumor rejection.</p>