AUTHOR=Jian Zhihong , Liu Rui , Zhu Xiqun , Smerin Daniel , Zhong Yi , Gu Lijuan , Fang Weirong , Xiong Xiaoxing 

TITLE=The Involvement and Therapy Target of Immune Cells After Ischemic Stroke

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.02167

DOI=10.3389/fimmu.2019.02167

ISSN=1664-3224

ABSTRACT=<p>After ischemic stroke, the integrity of the blood-brain barrier is compromised. Peripheral immune cells, including neutrophils, T cells, B cells, dendritic cells, and macrophages, infiltrate into the ischemic brain tissue and play an important role in regulating the progression of ischemic brain injury. In this review, we will discuss the role of different immune cells after stroke in the secondary inflammatory reaction and focus on the phenotypes and functions of macrophages in ischemic stroke, as well as briefly introduce the anti-ischemic stroke therapy targeting macrophages.</p>