AUTHOR=Sagan Agnieszka , Mikolajczyk Tomasz P. , Mrowiecki Wojciech , MacRitchie Neil , Daly Kevin , Meldrum Alan , Migliarino Serena , Delles Christian , Urbanski Karol , Filip Grzegorz , Kapelak Boguslaw , Maffia Pasquale , Touyz Rhian , Guzik Tomasz J. TITLE=T Cells Are Dominant Population in Human Abdominal Aortic Aneurysms and Their Infiltration in the Perivascular Tissue Correlates With Disease Severity JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01979 DOI=10.3389/fimmu.2019.01979 ISSN=1664-3224 ABSTRACT=
Abdominal Aortic Aneurysm (AAA) is a major cause of cardiovascular mortality. Adverse changes in vascular phenotype act in concert with chronic inflammation to promote AAA progression. Perivascular adipose tissue (PVAT) helps maintain vascular homeostasis but when inflamed and dysfunctional, can also promote vascular pathology. Previous studies suggested that PVAT may be an important site of vascular inflammation in AAA; however, a detailed assessment of leukocyte populations in human AAA, their anatomic location in the vessel wall and correlation to AAA size remain undefined. Accordingly, we performed in depth immunophenotyping of cells infiltrating the pathologically altered perivascular tissue (PVT) and vessel wall in AAA samples at the site of maximal dilatation (