AUTHOR=Babu Hemalatha , Ambikan Anoop T. , Gabriel Erin E. , Svensson Akusjärvi Sara , Palaniappan Alangudi Natarajan , Sundaraj Vijila , Mupanni Naveen Reddy , Sperk Maike , Cheedarla Narayanaiah , Sridhar Rathinam , Tripathy Srikanth P. , Nowak Piotr , Hanna Luke Elizabeth , Neogi Ujjwal TITLE=Systemic Inflammation and the Increased Risk of Inflamm-Aging and Age-Associated Diseases in People Living With HIV on Long Term Suppressive Antiretroviral Therapy JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01965 DOI=10.3389/fimmu.2019.01965 ISSN=1664-3224 ABSTRACT=
The ART program in low- and middle-income countries (LMIC) like India, follows a public health approach with a standardized regimen for all people living with HIV (PLHIV). Based on the evidence from high-income countries (HIC), the risk of an enhanced, and accentuated onset of premature-aging or age-related diseases has been observed in PLHIV. However, very limited data is available on residual inflammation and immune activation in the populations who are on first-generation anti-HIV drugs like zidovudine and lamivudine that have more toxic side effects. Therefore, the aim of the present study was to evaluate the levels of systemic inflammation and understand the risk of age-associated diseases in PLHIV on long-term suppressive ART using a large number of biomarkers of inflammation and immune activation. Blood samples were obtained from therapy naïve PLHIV (Pre-ART,