AUTHOR=Lin Heng , Li Shu , Shu Hong-Bing 

TITLE=The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01751

DOI=10.3389/fimmu.2019.01751

ISSN=1664-3224

ABSTRACT=<p>The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases have emerged as critical regulators of immune responses. MARCH proteins target immune receptors, viral proteins as well as components in innate immune response for polyubiquitination and degradations via distinct routes. This review summarizes the current progress about MARCH proteins and their regulation on immune responses.</p>