AUTHOR=Barrera Valentina , Haley Michael J. , Strangward Patrick , Attree Elizabeth , Kamiza Steve , Seydel Karl B. , Taylor Terrie E. , Milner Danny A. , Craig Alister G. , Couper Kevin N. 

TITLE=Comparison of CD8+ T Cell Accumulation in the Brain During Human and Murine Cerebral Malaria

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01747

DOI=10.3389/fimmu.2019.01747

ISSN=1664-3224

ABSTRACT=<p>CD8<sup>+</sup> T cells have been shown to play a critical role in the pathogenesis of experimental cerebral malaria (ECM) in mice, but their role in development of human cerebral malaria (HCM) remains unclear. Thus, in this study we have provided the first direct contrast of the accumulation of CD8<sup>+</sup> T cells in the brain during HCM and ECM. HCM cases were from children who died of <italic>Plasmodium falciparum</italic> cerebral malaria at Queen Elizabeth Central Hospital (Malawi) between 2003 and 2010. ECM was induced by infecting C57BL/6J mice with <italic>P. berghei</italic> ANKA. We demonstrate similarities in the intracerebral CD8<sup>+</sup> T cell responses in ECM and HCM, in particular an apparent shared choroid plexus—meningeal route of CD8<sup>+</sup> T cell accumulation in the brain. Nevertheless, we also reveal some potentially important differences in compartmentalization of CD8<sup>+</sup> T cells within the cerebrovascular bed in HCM and ECM.</p>