AUTHOR=Leija Montoya Gabriela , González Ramírez Javier , Sandoval Basilio Jorge , Serafín Higuera Idanya , Isiordia Espinoza Mario , González González Rogelio , Serafín Higuera Nicolás 

TITLE=Long Non-coding RNAs: Regulators of the Activity of Myeloid-Derived Suppressor Cells

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01734

DOI=10.3389/fimmu.2019.01734

ISSN=1664-3224

ABSTRACT=<p>Myeloid-derived suppressor cells (MDSCs) are a heterogeneous cell population with potent immunosuppressive functions. They play major roles in cancer and many of the pathologic conditions associated with inflammation. Long non-coding RNAs (lncRNAs) are untranslated functional RNA molecules. The lncRNAs are involved in the control of a wide variety of cellular processes and are dysregulated in different diseases. They can participate in the modulation of immune function and activity of inflammatory cells, including MDSCs. This mini review focuses on the emerging role of lncRNAs in MDSC activity. We summarize how lncRNAs modulate the generation, recruitment, and immunosuppressive functions of MDSCs and the underlying mechanisms.</p>