AUTHOR=Yap Xi Zen , Hustin Lucie S. P. , Sauerwein Robert W. 

TITLE=TH1-Polarized TFH Cells Delay Naturally-Acquired Immunity to Malaria

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01096

DOI=10.3389/fimmu.2019.01096

ISSN=1664-3224

ABSTRACT=<p>Humoral immunity is a critical effector arm for protection against malaria but develops only slowly after repeated infections. T cell-mediated regulatory dynamics affect the development of antibody responses to <italic>Plasmodium</italic> parasites. Here, we hypothesize that T follicular helper cell (T<sub>FH</sub>) polarization generated by repeated <italic>Plasmodium</italic> asexual blood-stage infections delays the onset of protective humoral responses. IFN-γ production promotes polarization toward T<sub>FH</sub>1 and increased generation of regulatory follicular helper cells (T<sub>FR</sub>). Delineating the mechanisms that drive T<sub>H</sub>1 polarization will provide clues for appropriate induction of lasting, protective immunity against malaria.</p>