AUTHOR=Couture Alexandre , Garnier Anthony , Docagne Fabian , Boyer Olivier , Vivien Denis , Le-Mauff Brigitte , Latouche Jean-Baptiste , Toutirais Olivier TITLE=HLA-Class II Artificial Antigen Presenting Cells in CD4+ T Cell-Based Immunotherapy JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.01081 DOI=10.3389/fimmu.2019.01081 ISSN=1664-3224 ABSTRACT=
CD4+ T cells differentiate into various T helper subsets characterized by distinct cytokine secreting profiles that confer them effector functions adapted to a variety of infectious or endogenous threats. Regulatory CD4+ T cells are another specialized subset that plays a fundamental role in the maintenance of immune tolerance to self-antigens. Manipulating effector or regulatory CD4+ T cells responses is a promising immunotherapy strategy for, respectively, chronical viral infections and cancer, or severe autoimmune diseases and transplantation. Adoptive cell therapy (ACT) is an emerging approach that necessitates defining robust and efficient methods for the