AUTHOR=Ahmad Fareed , Döbel Thomas , Schmitz Marc , Schäkel Knut 

TITLE=Current Concepts on 6-sulfo LacNAc Expressing Monocytes (slanMo)

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00948

DOI=10.3389/fimmu.2019.00948

ISSN=1664-3224

ABSTRACT=<p>The human mononuclear phagocytes system consists of dendritic cells (DCs), monocytes, and macrophages having different functions in bridging innate and adaptive immunity. Among the heterogeneous population of monocytes the cell surface marker slan (6-sulfo LacNAc) identifies a specific subset of human CD14<sup>−</sup> CD16<sup>+</sup> non-classical monocytes, called slan<sup>+</sup> monocytes (slanMo). In this review we discuss the identity and functions of slanMo, their contributions to immune surveillance by pro-inflammatory cytokine production, and cross talk with T cells and NK cells. We also consider the role of slanMo in the regulation of chronic inflammatory diseases and cancer. Finally, we highlight unresolved questions that should be the focus of future research.</p>