AUTHOR=Bucher Christian H. , Schlundt Claudia , Wulsten Dag , Sass F. Andrea , Wendler Sebastian , Ellinghaus Agnes , Thiele Tobias , Seemann Ricarda , Willie Bettina M. , Volk Hans-Dieter , Duda Georg N. , Schmidt-Bleek Katharina TITLE=Experience in the Adaptive Immunity Impacts Bone Homeostasis, Remodeling, and Healing JOURNAL=Frontiers in Immunology VOLUME=Volume 10 - 2019 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00797 DOI=10.3389/fimmu.2019.00797 ISSN=1664-3224 ABSTRACT=
Bone formation as well as bone healing capacity is known to be impaired in the elderly. Although bone formation is outpaced by bone resorption in aged individuals, we hereby present a novel path that considerably impacts bone formation and architecture: Bone formation is substantially reduced in aged individual owing to the experience of the adaptive immunity. Thus, immune-aging in addition to chronological aging is a potential risk factor, with an experienced immune system being recognized as more pro-inflammatory. The role of the aging immune system on bone homeostasis and on the bone healing cascade has so far not been considered. Within this study mice at different age and immunological experience were analyzed toward bone properties. Healing was assessed by introducing an osteotomy, immune cells were adoptively transferred to disclose the difference in biological vs. chronological aging.