AUTHOR=Huijbers Elisabeth J. M. , van der Werf Inge M. , Faber Lisette D. , Sialino Lena D. , van der Laan Pia , Holland Hanna A. , Cimpean Anca M. , Thijssen Victor L. J. L. , van Beijnum Judy R. , Griffioen Arjan W. TITLE=Targeting Tumor Vascular CD99 Inhibits Tumor Growth JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00651 DOI=10.3389/fimmu.2019.00651 ISSN=1664-3224 ABSTRACT=
CD99 (MIC2; single-chain type-1 glycoprotein) is a heavily O-glycosylated transmembrane protein (32 kDa) present on leukocytes and activated endothelium. Expression of CD99 on endothelium is important in lymphocyte diapedesis. CD99 is a diagnostic marker for Ewing's Sarcoma (EWS), as it is highly expressed by these tumors. It has been reported that CD99 can affect the migration, invasion and metastasis of tumor cells. Our results show that CD99 is also highly expressed in the tumor vasculature of most solid tumors. Furthermore, we found that