AUTHOR=Yu Xueping , Zheng Yijuan , Mao Richeng , Su Zhijun , Zhang Jiming 

TITLE=BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00617

DOI=10.3389/fimmu.2019.00617

ISSN=1664-3224

ABSTRACT=<p>B- and T-lymphocyte attenuator (BTLA) is an immune-regulatory receptor, similar to CTLA-4 and PD-1, and is mainly expressed on B-, T-, and all mature lymphocyte cells. Herpes virus entry mediator (HVEM)-BTLA plays a critical role in immune tolerance and immune responses which are areas of intense research. However, the mechanisms of the BTLA and the BTLA/HVEM signaling pathway in human diseases remain unclear. This review describes the research milestones of BTLA and HVEM in chronological order and their role in chronic HBV infection.</p>