AUTHOR=Le Stephanie T. , Merleev Alexander A. , Luxardi Guillaume , Shimoda Michiko , Adamopoulos Iannis E. , Tsoi Lam C. , Wang Jenny Z. , Alexanian Claire , Raychaudhuri Siba P. , Hwang Samuel T. , Gudjonsson Johann , Marusina Alina I. , Maverakis Emanual TITLE=2D Visualization of the Psoriasis Transcriptome Fails to Support the Existence of Dual-Secreting IL-17A/IL-22 Th17 T Cells JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00589 DOI=10.3389/fimmu.2019.00589 ISSN=1664-3224 ABSTRACT=
The present paradigm of psoriasis pathogenesis revolves around the IL-23/IL-17A axis. Dual-secreting Th17 T cells presumably are the predominant sources of the psoriasis phenotype-driving cytokines, IL-17A and IL-22. We thus conducted a meta-analysis of independently acquired RNA-seq psoriasis datasets to explore the relationship between the expression of