AUTHOR=Siddiqui Yasir Dilshad , Omori Kazuhiro , Ito Takashi , Yamashiro Keisuke , Nakamura Shin , Okamoto Kentaro , Ono Mitsuaki , Yamamoto Tadashi , Van Dyke Thomas E. , Takashiba Shogo TITLE=Resolvin D2 Induces Resolution of Periapical Inflammation and Promotes Healing of Periapical Lesions in Rat Periapical Periodontitis JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00307 DOI=10.3389/fimmu.2019.00307 ISSN=1664-3224 ABSTRACT=
Periapical periodontitis results from pulpal infection leading to pulpal necrosis and resorption of periapical bone. The current treatment is root canal therapy, which attempts to eliminate infection and necrotic tissue. But, in some cases periapical inflammation doesn't resolve even after treatment. Resolvins belongs to a large family of specialized pro-resolving lipid mediators that actively resolves inflammation signaling via specific receptors. Resolvin D2 (RvD2), a metabolite of docosahexaenoic acid (DHA), was tested as an intracanal medicament in rats