AUTHOR=Yao Xiaoying , Dong Guanjun , Zhu Yuzhen , Yan Fenglian , Zhang Hui , Ma Qun , Fu Xingqin , Li Xuehui , Zhang QingQing , Zhang Junfeng , Shi Hui , Ning Zhaochen , Dai Jun , Li Zhihua , Li Chunxia , Wang Bo , Ming Jiankuo , Yang Yonghong , Hong Feng , Meng Xiangzhi , Xiong Huabao , Si Chuanping TITLE=Leukadherin-1-Mediated Activation of CD11b Inhibits LPS-Induced Pro-inflammatory Response in Macrophages and Protects Mice Against Endotoxic Shock by Blocking LPS-TLR4 Interaction JOURNAL=Frontiers in Immunology VOLUME=10 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00215 DOI=10.3389/fimmu.2019.00215 ISSN=1664-3224 ABSTRACT=
Dysregulation of macrophage has been demonstrated to contribute to aberrant immune responses and inflammatory diseases. CD11b, expressed on macrophages, plays a critical role in regulating pathogen recognition, phagocytosis, and cell survival. In the present study, we explored the effect of leukadherin-1 (LA1), an agonist of CD11b, on regulating LPS-induced pro-inflammatory response in macrophages and endotoxic shock. Intriguingly, we found that LA1 could significantly reduce mortalities of mice and alleviated pathological injury of liver and lung in endotoxic shock.