AUTHOR=Ssemaganda Aloysious , Giddam Ashwini Kumar , Zaman Mehfuz , Skwarczynski Mariusz , Toth Istvan , Stanisic Danielle I. , Good Michael F. 

TITLE=Induction of Plasmodium-Specific Immune Responses Using Liposome-Based Vaccines

JOURNAL=Frontiers in Immunology

VOLUME=10

YEAR=2019

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2019.00135

DOI=10.3389/fimmu.2019.00135

ISSN=1664-3224

ABSTRACT=<p>In the development of vaccines, the ability to initiate both innate and subsequent adaptive immune responses need to be considered. Live attenuated vaccines achieve this naturally, while inactivated and sub-unit vaccines generally require additional help provided through delivery systems and/or adjuvants. Liposomes present an attractive adjuvant/delivery system for antigens. Here, we review the key aspects of immunity against <italic>Plasmodium</italic> parasites, liposome design considerations and their current application in the development of a malaria vaccine.</p>