AUTHOR=Maria Alexandre Thibault Jacques , Partouche Léo , Goulabchand Radjiv , Rivière Sophie , Rozier Pauline , Bourgier Céline , Le Quellec Alain , Morel Jacques , Noël Danièle , Guilpain Philippe TITLE=Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.03112 DOI=10.3389/fimmu.2018.03112 ISSN=1664-3224 ABSTRACT=

Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is observed in SSc (including breast and lung cancers), and in a subgroup of patients with specific autoantibodies (i.e., anti-RNA polymerase III and related autoantibodies), SSc could be a paraneoplastic syndrome and might be directly related to an immune response against cancer. Herein, we reviewed the literature, focusing on the most recent articles, and shed light onto the potential relationship between cancer and scleroderma regarding temporal and immunological dimensions.