AUTHOR=Li Jingwen , Yin Wei , Jing Yukai , Kang Danqing , Yang Lu , Cheng Jiali , Yu Ze , Peng Zican , Li Xingbo , Wen Yue , Sun Xizi , Ren Boxu , Liu Chaohong TITLE=The Coordination Between B Cell Receptor Signaling and the Actin Cytoskeleton During B Cell Activation JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.03096 DOI=10.3389/fimmu.2018.03096 ISSN=1664-3224 ABSTRACT=

B-cell activation plays a crucial part in the immune system and is initiated via interaction between the B cell receptor (BCR) and specific antigens. In recent years with the help of modern imaging techniques, it was found that the cortical actin cytoskeleton changes dramatically during B-cell activation. In this review, we discuss how actin-cytoskeleton reorganization regulates BCR signaling in different stages of B-cell activation, specifically when stimulated by antigens, and also how this reorganization is mediated by BCR signaling molecules. Abnormal BCR signaling is associated with the progression of lymphoma and immunological diseases including autoimmune disorders, and recent studies have proved that impaired actin cytoskeleton can devastate the normal activation of B cells. Therefore, to figure out the coordination between the actin cytoskeleton and BCR signaling may reveal an underlying mechanism of B-cell activation, which has potential for new treatments for B-cell associated diseases.