AUTHOR=Wattegedera Sean R. , Doull Laura E. , Goncheva Mariya I. , Wheelhouse Nicholas M. , Watson Donna M. , Pearce Julian , Benavides Julio , Palarea-Albaladejo Javier , McInnes Colin J. , Ballingall Keith , Entrican Gary TITLE=Immunological Homeostasis at the Ovine Placenta May Reflect the Degree of Maternal Fetal Interaction JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2019 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.03025 DOI=10.3389/fimmu.2018.03025 ISSN=1664-3224 ABSTRACT=
Successful mammalian pregnancies are a result of complex physiological, endocrinological, and immunological processes that combine to create an environment where the mother is tolerant to the semi-allogeneic fetus. Our knowledge of the mechanisms that contribute to maternal tolerance is derived mainly from human and murine studies of haemochorial placentation. However, as this is the most invasive type of placentation it cannot be assumed that identical mechanisms apply to the less invasive epitheliochorial placentation found in other species such as ruminants. Here, we examine three features associated with reproductive immune regulation in a transformed ovine trophoblast cell line and