AUTHOR=Agresta Laura , Hoebe Kasper H. N. , Janssen Edith M. 

TITLE=The Emerging Role of CD244 Signaling in Immune Cells of the Tumor Microenvironment

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.02809

DOI=10.3389/fimmu.2018.02809

ISSN=1664-3224

ABSTRACT=<p>In cancer, immune exhaustion contributes to the immunosuppressive tumor microenvironment. Exhausted immune cells demonstrate poor effector function and sustained expression of certain immunomodulatory receptors, which can be therapeutically targeted. CD244 is a Signaling Lymphocyte Activation Molecule (SLAM) family immunoregulatory receptor found on many immune cell types—including NK cells, a subset of T cells, DCs, and MDSCs—that represents a potential therapeutic target. Here, we discuss the role of CD244 in tumor-mediated immune cell regulation.</p>