AUTHOR=Rossy Jérémie , Laufer Julia M. , Legler Daniel F. 

TITLE=Role of Mechanotransduction and Tension in T Cell Function

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.02638

DOI=10.3389/fimmu.2018.02638

ISSN=1664-3224

ABSTRACT=<p>T cell migration from blood to, and within lymphoid organs and tissue, as well as, T cell activation rely on complex biochemical signaling events. But T cell migration and activation also take place in distinct mechanical environments and lead to drastic morphological changes and reorganization of the acto-myosin cytoskeleton. In this review we discuss how adhesion proteins and the T cell receptor act as mechanosensors to translate these mechanical contexts into signaling events. We further discuss how cell tension could bring a significant contribution to the regulation of T cell signaling and function.</p>