AUTHOR=Peer Sebastian , Cappellano Giuseppe , Hermann-Kleiter Natascha , Albrecht-Schgoer Karin , Hinterleitner Reinhard , Baier Gottfried , Gruber Thomas TITLE=Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.02311 DOI=10.3389/fimmu.2018.02311 ISSN=1664-3224 ABSTRACT=
Genome-wide association studies as well as lymphatic expression analyses have linked both Cbl-b and GM-CSF to human multiple sclerosis as well as other autoimmune diseases. Both Cbl-b and GM-CSF have been shown to play a prominent role in the development of murine encephalomyelitis; however, no functional connection between the two has yet been established. In this study, we show that