AUTHOR=Rodríguez-Galán Ana , Fernández-Messina Lola , Sánchez-Madrid Francisco 

TITLE=Control of Immunoregulatory Molecules by miRNAs in T Cell Activation

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.02148

DOI=10.3389/fimmu.2018.02148

ISSN=1664-3224

ABSTRACT=<p>MiRNA targeting of key immunoregulatory molecules fine-tunes the immune response. This mechanism boosts or dampens immune functions to preserve homeostasis while supporting the full development of effector functions. MiRNA expression changes during T cell activation, highlighting that their function is constrained by a specific spatiotemporal frame related to the signals that induce T cell-based effector functions. Here, we update the state of the art regarding the miRNAs that are differentially expressed during T cell stimulation. We also revisit the existing data on miRNA function in T cell activation, with a special focus on the modulation of the most relevant immunoregulatory molecules.</p>