AUTHOR=Di Ianni Mauro , Del Papa Beatrice , Baldoni Stefano , Di Tommaso Ambra , Fabi Bianca , Rosati Emanuela , Natale Annalisa , Santarone Stella , Olioso Paola , Papalinetti Gabriele , Giancola Raffaella , Accorsi Patrizia , Di Bartolomeo Paolo , Sportoletti Paolo , Falzetti Franca 

TITLE=NOTCH and Graft-Versus-Host Disease

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01825

DOI=10.3389/fimmu.2018.01825

ISSN=1664-3224

ABSTRACT=<p>In allogeneic hematopoietic stem cell transplantation, which is the major curative therapy for hematological malignancies, T cells play a key role in the development of graft-versus-host disease (GvHD). NOTCH pathway is a conserved signal transduction system that regulates T cell development and differentiation. The present review analyses the role of the NOTCH signaling as a new regulator of acute GvHD. NOTCH signaling could also represent a new therapeutic target for GvHD.</p>