AUTHOR=Zou Fagui , Wang Xu , Han Xinxin , Rothschild Gerson , Zheng Song Guo , Basu Uttiya , Sun Jianbo 

TITLE=Expression and Function of Tetraspanins and Their Interacting Partners in B Cells

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01606

DOI=10.3389/fimmu.2018.01606

ISSN=1664-3224

ABSTRACT=<p>Tetraspanins are transmembrane proteins that modulate multiple diverse biological processes, including signal transduction, cell–cell communication, immunoregulation, tumorigenesis, cell adhesion, migration, and growth and differentiation. Here, we provide a systematic review of the involvement of tetraspanins and their partners in the regulation and function of B cells, including mechanisms associated with antigen presentation, antibody production, cytokine secretion, co-stimulator expression, and immunosuppression. Finally, we direct our focus to the signaling mechanisms, evolutionary conservation aspects, expression, and potential therapeutic strategies that could be based on tetraspanins and their interacting partners.</p>