AUTHOR=Chulpanova Daria S. , Kitaeva Kristina V. , James Victoria , Rizvanov Albert A. , Solovyeva Valeriya V. TITLE=Therapeutic Prospects of Extracellular Vesicles in Cancer Treatment JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01534 DOI=10.3389/fimmu.2018.01534 ISSN=1664-3224 ABSTRACT=
Extracellular vesicles (EVs) are released by all cells within the tumor microenvironment, such as endothelial cells, tumor-associated fibroblasts, pericytes, and immune system cells. The EVs carry the cargo of parental cells formed of proteins and nucleic acids, which can convey cell-to-cell communication influencing the maintenance and spread of the malignant neoplasm, for example, promoting angiogenesis, tumor cell invasion, and immune escape. However, EVs can also suppress tumor progression, either by the direct influence of the protein and nucleic acid cargo of the EVs or