AUTHOR=Yang Yunben , Xu Chunjing , Wu Dang , Wang Zhen , Wu Pin , Li Lili , Huang Jian , Qiu Fuming TITLE=γδ T Cells: Crosstalk Between Microbiota, Chronic Inflammation, and Colorectal Cancer JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01483 DOI=10.3389/fimmu.2018.01483 ISSN=1664-3224 ABSTRACT=

Increasing evidence suggests that intestinal microbiota dysbiosis and chronic inflammation contribute to colorectal cancer (CRC) development. γδ T cells represent a major innate immune cell population in the intestinal epithelium that is involved in the maintenance of gut homeostasis, inflammation regulation, and carcinogenesis. The important contributions of γδ T cells are (i) to perform a protective role in the context of barrier damage and pathogenic microorganism translocation; (ii) to exert either pro- or anti-inflammatory effects at different inflammatory stages; and (iii) to boost the crosstalk between immune cells and tumor microenvironment, inducing a cascade of suppressive immune responses. Understanding the crucial role of γδ T cells would enable us to manipulate these cells during the CRC sequence and improve the efficacy of tumor therapy.