AUTHOR=Martín-Cófreces Noa Beatriz , Sánchez-Madrid Francisco 

TITLE=Sailing to and Docking at the Immune Synapse: Role of Tubulin Dynamics and Molecular Motors

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01174

DOI=10.3389/fimmu.2018.01174

ISSN=1664-3224

ABSTRACT=<p>The different cytoskeleton systems and their connecting molecular motors move vesicles and intracellular organelles to shape cells. Polarized cells with specialized functions display an exquisite spatio-temporal regulation of both cytoskeletal and organelle arrangements that support their specific tasks. In particular, T cells rapidly change their shape and cellular function through the establishment of cell surface and intracellular polarity in response to a variety of cues. This review focuses on the contribution of the microtubule-based dynein/dynactin motor complex, the tubulin and actin cytoskeletons, and different organelles to the formation of the antigen-driven immune synapse.</p>