AUTHOR=Sheng Yuqiao , Li Feng , Qin Zhihai 

TITLE=TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors

JOURNAL=Frontiers in Immunology

VOLUME=9

YEAR=2018

URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.01170

DOI=10.3389/fimmu.2018.01170

ISSN=1664-3224

ABSTRACT=<p>Tumor necrosis factor (TNF) is widely accepted as a tumor-suppressive cytokine <italic>via</italic> its ubiquitous receptor TNF receptor 1 (TNFR1). The other receptor, TNFR2, is not only expressed on some tumor cells but also on suppressive immune cells, including regulatory T cells and myeloid-derived suppressor cells. In contrast to TNFR1, TNFR2 diverts the tumor-inhibiting TNF into a tumor-advocating factor. TNFR2 directly promotes the proliferation of some kinds of tumor cells. Also activating immunosuppressive cells, it supports immune escape and tumor development. Hence, TNFR2 may represent a potential target of cancer therapy. Here, we focus on expression and role of TNFR2 in the tumor microenvironment. We summarize the recent progress in understanding how TNFR2-dependent mechanisms promote carcinogenesis and tumor growth and discuss the potential value of TNFR2 in cancer treatment.</p>