AUTHOR=Morgan Sophie B. , Holzer Barbara , Hemmink Johanneke D. , Salguero Francisco J. , Schwartz John C. , Agatic Gloria , Cameroni Elisabetta , Guarino Barbara , Porter Emily , Rijal Pramila , Townsend Alain , Charleston Bryan , Corti Davide , Tchilian Elma TITLE=Therapeutic Administration of Broadly Neutralizing FI6 Antibody Reveals Lack of Interaction Between Human IgG1 and Pig Fc Receptors JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00865 DOI=10.3389/fimmu.2018.00865 ISSN=1664-3224 ABSTRACT=
Influenza virus infection is a significant global health threat. Because of the lack of cross-protective universal vaccines, short time window during which antivirals are effective and drug resistance, new therapeutic anti-influenza strategies are required. Broadly, cross-protective antibodies that target conserved sites in the hemagglutinin (HA) stem region have been proposed as therapeutic agents. FI6 is the first proven such monoclonal antibody to bind to H1–H16 and is protective in mice and ferrets. Multiple studies have shown that Fc-dependent mechanisms are essential for FI6