AUTHOR=Slowicka Karolina , van Loo Geert TITLE=Optineurin Functions for Optimal Immunity JOURNAL=Frontiers in Immunology VOLUME=9 YEAR=2018 URL=https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2018.00769 DOI=10.3389/fimmu.2018.00769 ISSN=1664-3224 ABSTRACT=
Optineurin (OPTN) was identified 20 years ago in a yeast-two-hybrid screen with a viral protein known to inhibit the cytolytic effects of tumor necrosis factor. Since then, OPTN has been identified as a ubiquitin-binding protein involved in many signaling pathways and cellular processes, and mutations in the